RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by
multiple features consistent with accelerated aging. It is caused by null mutations of the …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

The discovery of telomeres dates back to the early 20th century. In humans, telomeres are
heterochromatic structures with tandem DNA repeats of 5′‐TTAGGG‐3′ at the …

ERCC1–XPF is a structure-specific endonuclease required for nucleotide excision repair,
interstrand crosslink repair, and the repair of some double-strand breaks. Mutations in …

During space travel astronauts are exposed to a variety of radiations, including galactic
cosmic rays composed of high-energy protons and high-energy charged (HZE) nuclei, and …

Genomic instability is a hallmark of cancer and aging. Premature aging (progeroid)
syndromes are often caused by mutations in genes whose function is to ensure genomic …

Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of
embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to …

Telomeres are structures at the ends of chromosomes and are composed of long tracks of
short tandem repeat DNA sequences bound by a unique set of proteins (shelterin) …

Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent
stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without …