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Modern approaches for asymmetric construction of carbon–fluorine quaternary stereogenic centers: synthetic challenges and pharmaceutical needs
New methods for preparation of tailor-made fluorine-containing compounds are in extremely
high demand in nearly every sector of chemical industry. The asymmetric construction of …
high demand in nearly every sector of chemical industry. The asymmetric construction of …
Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …
Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …
interconnected research fields. These include the development of new materials with a …
Applications of fluorine-containing amino acids for drug design
Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …
Recent advances in the synthesis of fluorinated aminophosphonates and aminophosphonic acids
This review article surveys recent achievements in the preparation and biological properties
evaluation of fluorinated aminophosphonates and aminophosphonic acids. Recently, in …
evaluation of fluorinated aminophosphonates and aminophosphonic acids. Recently, in …
Recent advances in synthesis of difluoromethylene phosphonates for biological applications
M Shevchuk, Q Wang, R Pajkert, J Xu… - Advanced Synthesis …, 2021 - Wiley Online Library
For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular
tools in biochemical studies owing to their close resemblance to naturally occurring …
tools in biochemical studies owing to their close resemblance to naturally occurring …
Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni (II) complexes
Y Wang, X Song, J Wang, H Moriwaki, VA Soloshonok… - Amino Acids, 2017 - Springer
This review article critically discusses examples of asymmetric synthesis of tailor-made α-
amino acids via homologation of Ni (II) complexes of glycine and alanine Schiff bases …
amino acids via homologation of Ni (II) complexes of glycine and alanine Schiff bases …
Tailor-made amino acids in the design of small-molecule blockbuster drugs
The role of amino acids (AAs) in modern health industry is well-appreciated. Residues of
individual AAs, or their chemical modifications, such as diamines and amino alcohols, are …
individual AAs, or their chemical modifications, such as diamines and amino alcohols, are …
Successful trifluoromethoxy-containing pharmaceuticals and agrochemicals
Trifluoromethoxy-containing molecules represent still underdeveloped, but highly promising
group of biologically active compounds. The first part of this review profiles five known …
group of biologically active compounds. The first part of this review profiles five known …
Phosphonopeptides containing free phosphonic groups: recent advances
P Kafarski - RSC advances, 2020 - pubs.rsc.org
Phosphonopeptides are mimetics of peptides in which phosphonic acid or related
(phosphinic, phosphonous etc.) group replaces either carboxylic acid group present at C …
(phosphinic, phosphonous etc.) group replaces either carboxylic acid group present at C …
Detrifluoroacetylative in situ generation of free 3-fluoroindolin-2-one-derived tertiary enolates: design, synthesis, and assessment of reactivity toward asymmetric …
The discovery of detrifluoroacetylative in situ generation of a new type of fluorinated amide
enolates derived from 3-fluoroindolin-2-one and their asymmetric Mannich additions with …
enolates derived from 3-fluoroindolin-2-one and their asymmetric Mannich additions with …