Modern approaches for asymmetric construction of carbon–fluorine quaternary stereogenic centers: synthetic challenges and pharmaceutical needs

Y Zhu, J Han, J Wang, N Shibata, M Sodeoka… - Chemical …, 2018 - ACS Publications
New methods for preparation of tailor-made fluorine-containing compounds are in extremely
high demand in nearly every sector of chemical industry. The asymmetric construction of …

Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …

Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Applications of fluorine-containing amino acids for drug design

H Mei, J Han, KD Klika, K Izawa, T Sato… - European journal of …, 2020 - Elsevier
Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Recent advances in the synthesis of fluorinated aminophosphonates and aminophosphonic acids

KV Turcheniuk, VP Kukhar, GV Röschenthaler… - RSC Advances, 2013 - pubs.rsc.org
This review article surveys recent achievements in the preparation and biological properties
evaluation of fluorinated aminophosphonates and aminophosphonic acids. Recently, in …

Recent advances in synthesis of difluoromethylene phosphonates for biological applications

M Shevchuk, Q Wang, R Pajkert, J Xu… - Advanced Synthesis …, 2021 - Wiley Online Library
For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular
tools in biochemical studies owing to their close resemblance to naturally occurring …

Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni (II) complexes

Y Wang, X Song, J Wang, H Moriwaki, VA Soloshonok… - Amino Acids, 2017 - Springer
This review article critically discusses examples of asymmetric synthesis of tailor-made α-
amino acids via homologation of Ni (II) complexes of glycine and alanine Schiff bases …

Tailor-made amino acids in the design of small-molecule blockbuster drugs

J Han, H Konno, T Sato, VA Soloshonok… - European Journal of …, 2021 - Elsevier
The role of amino acids (AAs) in modern health industry is well-appreciated. Residues of
individual AAs, or their chemical modifications, such as diamines and amino alcohols, are …

Successful trifluoromethoxy-containing pharmaceuticals and agrochemicals

J Liu, W Lin, AE Sorochinsky, G Butler, A Landa… - Journal of Fluorine …, 2022 - Elsevier
Trifluoromethoxy-containing molecules represent still underdeveloped, but highly promising
group of biologically active compounds. The first part of this review profiles five known …

Phosphonopeptides containing free phosphonic groups: recent advances

P Kafarski - RSC advances, 2020 - pubs.rsc.org
Phosphonopeptides are mimetics of peptides in which phosphonic acid or related
(phosphinic, phosphonous etc.) group replaces either carboxylic acid group present at C …

Detrifluoroacetylative in situ generation of free 3-fluoroindolin-2-one-derived tertiary enolates: design, synthesis, and assessment of reactivity toward asymmetric …

C **e, L Zhang, W Sha, VA Soloshonok, J Han… - Organic …, 2016 - ACS Publications
The discovery of detrifluoroacetylative in situ generation of a new type of fluorinated amide
enolates derived from 3-fluoroindolin-2-one and their asymmetric Mannich additions with …