Recent advances in nanoparticulate RNA delivery systems
Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
[HTML][HTML] Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems,
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …
Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and In Situ Nucleic Acid Complexation
Ionisable amino‐lipid is a key component in lipid nanoparticles (LNPs), which plays a crucial
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function
J Philipp, A Dabkowska, A Reiser… - Proceedings of the …, 2023 - National Acad Sciences
Lipid nanoparticles (LNPs) are advanced core-shell particles for messenger RNA (mRNA)
based therapies that are made of polyethylene glycol (PEG) lipid …
based therapies that are made of polyethylene glycol (PEG) lipid …
Correlating the structure and gene silencing activity of oligonucleotide-loaded lipid nanoparticles using small-angle X-ray scattering
With three FDA-approved products, lipid nanoparticles (LNPs) are under intensive
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …
Inverse cubic and hexagonal mesophase evolution within ionizable lipid nanoparticles correlates with mRNA transfection in macrophages
mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
Transient inhibition of lysosomal functions potentiates nucleic acid vaccines
C Wang, A Karlsson, TH Oguin III… - Proceedings of the …, 2023 - National Acad Sciences
Nucleic acid vaccines have shown promising results in the clinic against infectious diseases
and cancers. To robustly improve the vaccine efficacy and safety, we developed an …
and cancers. To robustly improve the vaccine efficacy and safety, we developed an …
[HTML][HTML] Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids
J Bader, F Brigger, JC Leroux - Advanced Drug Delivery Reviews, 2024 - Elsevier
Extracellular vesicles (EVs) are increasingly investigated for delivering nucleic acid (NA)
therapeutics, leveraging their natural role in transporting NA and protein-based cargo in cell …
therapeutics, leveraging their natural role in transporting NA and protein-based cargo in cell …
Physicochemical and structural insights into lyophilized mRNA-LNP from lyoprotectant and buffer screenings
The surge in RNA therapeutics has revolutionized treatments for infectious diseases like
COVID-19 and shows the potential to expand into other therapeutic areas. However, the …
COVID-19 and shows the potential to expand into other therapeutic areas. However, the …
Theranostic Lipid Nanoparticles for Renal Cell Carcinoma
X Mao, G Wang, Z Wang, C Duan, X Wu… - Advanced …, 2023 - Wiley Online Library
Renal cell carcinoma (RCC) is a common urological malignancy and represents a leading
threat to healthcare. Recent years have seen a series of progresses in the early diagnosis …
threat to healthcare. Recent years have seen a series of progresses in the early diagnosis …