Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

Blockade of angiogenesis can retard tumour growth, but may also paradoxically increase
metastasis,. This paradox may be resolved by vessel normalization, which involves …

Cellular senescence has been shown to contribute to skin ageing. However, the role of
melanocytes in the process is understudied. Our data show that melanocytes are the only …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Abstract IFN-γ-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells
stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells …

C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10kDa (IP-
10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family …