Decades ago, mitogen-promoted signaling duration and strength were observed to be
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …

Abstract In 1972 the Fluid—Mosaic Membrane Model of membrane structure was proposed
based on thermodynamic principals of organization of membrane lipids and proteins and …

Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi,
viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic …

Sphingolipids play important roles in plasma membrane structure and cell signaling.
However, their lateral distribution in the plasma membrane is poorly understood. Here we …

This article reviews the current knowledge and recent advancements in computational
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

The process of choosing the most proper technique for studying the molecular interactions is
based on critical factors such as instrumentation complexity, automation, experimental …

The maintenance of ion channel homeostasis, or channelostasis, is a complex puzzle in
neurons with extensive dendritic arborization, encompassing a combinatorial diversity of …

In many cellular signaling pathways, key components form clusters at the cell membrane.
Although much work has focused on the mechanisms behind such cluster formation, the …

Advances in fluorescence microscopy have enabled the study of membrane diffusion, cell
adhesion and signal transduction at the molecular level in living cells grown in culture. By …