Targeting ferroptosis as a vulnerability in cancer
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
Disulfidptosis: disulfide stress–induced cell death
X Liu, L Zhuang, B Gan - Trends in cell biology, 2024 - cell.com
The cystine transporter solute carrier family 7 member 11 (SLC7A11)(also known as xCT)
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …
The role of ROS in tumour development and progression
EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
Metal-based photosensitizers as inducers of regulated cell death mechanisms
Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …
discovered and were found to improve cancer treatment. Although there are several reviews …
A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers
Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …
Ferroptosis in cancer and cancer immunotherapy
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …
Disulfidptosis: a new target for metabolic cancer therapy
P Zheng, C Zhou, Y Ding, S Duan - Journal of Experimental & Clinical …, 2023 - Springer
Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited
in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic …
in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic …
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is
a key tumour suppression mechanism,,–. Glutathione peroxidase 4 (GPX4), and ferroptosis …
a key tumour suppression mechanism,,–. Glutathione peroxidase 4 (GPX4), and ferroptosis …
[HTML][HTML] SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …