Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …
proportions and now affecting more than one billion people worldwide. These diseases are …
Disease modification in inflammatory skin disorders: opportunities and challenges
T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …
Artificial intelligence: exploring the future of innovation in allergy immunology
D MacMath, M Chen, P Khoury - Current Allergy and Asthma Reports, 2023 - Springer
Abstract Purpose of Review Artificial intelligence (AI) has increasingly been used in
healthcare. Given the capacity of AI to handle large data and complex relationships between …
healthcare. Given the capacity of AI to handle large data and complex relationships between …
[HTML][HTML] Phthalate exposure and allergic diseases: Review of epidemiological and experimental evidence
Phthalates are among the most ubiquitous environmental contaminants and endocrine-
disrupting chemicals. Exposure to phthalates and related health effects have been …
disrupting chemicals. Exposure to phthalates and related health effects have been …
New biological treatments for asthma and skin allergies
S Eyerich, M Metz, A Bossios, K Eyerich - Allergy, 2020 - Wiley Online Library
Allergies are typically endemic, complex and heterogeneous diseases with a high impact at
quality of life. Mechanistically, type 2 immune responses involving eosinophil and basophil …
quality of life. Mechanistically, type 2 immune responses involving eosinophil and basophil …
Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin
Background Epithelial barrier impairment is associated with many skin and mucosal
inflammatory disorders. Laundry detergents have been demonstrated to affect epithelial …
inflammatory disorders. Laundry detergents have been demonstrated to affect epithelial …
Genetics of atopic dermatitis: from DNA sequence to clinical relevance
Atopic dermatitis (AD) is a complex disease that is thought to be triggered by environmental
factors in genetically susceptible individuals. Twin studies have estimated the heritability of …
factors in genetically susceptible individuals. Twin studies have estimated the heritability of …
Efficacy and safety of dupilumab for moderate‐to‐severe atopic dermatitis: a systematic review for the EAACI biologicals guidelines
This systematic review evaluates the efficacy, safety and economic impact of dupilumab
compared to standard of care for uncontrolled moderate‐to‐severe atopic dermatitis (AD) …
compared to standard of care for uncontrolled moderate‐to‐severe atopic dermatitis (AD) …
Advances in atopic dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune …
T Nomura, K Kabashima - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Key research advances in atopic dermatitis (AD) suggest the complexity of its endotypes. A
comprehensive serum biomarker panel revealed at least 4 types of AD. Some represent …
comprehensive serum biomarker panel revealed at least 4 types of AD. Some represent …
Educational and psychological interventions for managing atopic dermatitis (eczema)
Background Atopic dermatitis (eczema), can have a significant impact on well‐being and
quality of life for affected people and their families. Standard treatment is avoidance of …
quality of life for affected people and their families. Standard treatment is avoidance of …