Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

Endolysins are enzymes used by bacteriophages at the end of their replication cycle to
degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release …

Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

Worldwide, bacterial resistance to chemical antibiotics has reached such a high level that
endangers public health. Presently, the adoption of alternative strategies that promote the …

Endolysins (or lysins) are highly evolved enzymes produced by bacteriophage (phage for
short) to digest the bacterial cell wall for phage progeny release. In Gram-positive bacteria …

Soon after their discovery in the early 20th century, bacteriophages were recognized to have
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …

Endolysins are phage-encoded enzymes that break down bacterial peptidoglycan at the
terminal stage of the phage reproduction cycle. Their action is tightly regulated by holins, by …

Lysins are highly evolved enzymes produced by bacteriophage (phage for short) to digest
the bacterial cell wall for phage progeny release. In Gram-positive bacteria, small quantities …

Bacteriophage (phage) therapy involves using phages or their products as bioagents for the
treatment or prophylaxis of bacterial infectious diseases. Much evidence in support of the …