RAS GTPases play essential roles in normal development and are direct drivers of human
cancers. Three decades of study have failed to wholly characterize pathways stimulated by …

The notion that invasive cancer is a product of somatic evolution is a well-established theory
that can be modelled mathematically and demonstrated empirically from therapeutic …

Aberrantly activated kinase signaling pathways drive invasion and dissemination in
medulloblastoma (MB). A majority of tumor-promoting kinase signaling pathways feed into …

We have previously reported that F1012‐2, a sesquiterpene lactone isolated from the
Chinese herbal medicine Eupatorium lindleyanum DC., exhibits strong effects against Triple …

Signal transduction pathways are responsible for maintaining cellular functions, including
proliferation, differentiation, apoptosis, and cell cycle progression. These pathways are …

Intravital imaging is a powerful technology used to quantify and track dynamic changes in
live cells and tissues within an intact environment. The ability to watch cell biology in real …

Conventional biochemical methods for studying cellular signaling cascades have relied on
destructive cell disruption. In contrast, the live cell imaging of fluorescent-tagged transfected …

Therapies targeting mutated RAS, the most frequently mutated oncogene in human cancers,
could benefit millions of patients. Recently approved RAS inhibitors represent a …

Aberrant ERK activity can lead to uncontrolled cell proliferation, immortalization, and
impaired cell differentiation. Impairment of normal cell differentiation is one of the critical …

Cancer metastasis initiates by invasion of subsets of cells away from the primary tumour into
the surrounding stroma. Cells interact with surrounding extracellular matrix (ECM) through …