[HTML][HTML] Pharmacological activity, pharmacokinetics, and clinical research progress of puerarin

D Wang, T Bu, Y Li, Y He, F Yang, L Zou - Antioxidants, 2022 - mdpi.com
As a kind of medicine and food homologous plant, kudzu root (Pueraria lobata (Willd.) Ohwi)
is called an “official medicine” in Chinese folk medicine. Puerarin is the main active …

Ulcerative colitis: molecular insights and intervention therapy

Y Liang, Y Li, C Lee, Z Yu, C Chen, C Liang - Molecular biomedicine, 2024 - Springer
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal
pain, diarrhea, rectal bleeding, and weight loss. The pathogenesis and treatment of UC …

Surfactant-free, self-assembled nanomicelles-based transdermal hydrogel for safe and targeted delivery of methotrexate against rheumatoid arthritis

M Qindeel, D Khan, N Ahmed, S Khan… - ACS …, 2020 - ACS Publications
Methotrexate (MTX) is the first line agent for therapy against rheumatoid arthritis (RA);
however, orally its efficacy is hampered by poor solubility, less permeability, short plasma …

Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice

H Ullah, A Khan, MW Baig, N Ullah, N Ahmed… - … medicine and therapies, 2020 - Springer
Background In the present study, the poncirin which is flavonoid-7-o-glycosides (isolated
from the Poncirus trifoliata) in nature was evaluated against the Carbon tetra chloride …

Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-κβ pathway

E Sana, M Zeeshan, QU Ain, AU Khan, I Hussain… - …, 2021 - Taylor & Francis
Aim: To fabricate and evaluate curcumin-loaded transfersomes (Cur-TF) for the targeted
delivery and enhanced therapeutic efficacy of curcumin for the treatment of rheumatoid …

Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling

Z Kazmi, S Zeeshan, A Khan, S Malik, A Shehzad… - Neurotoxicology, 2020 - Elsevier
Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent
seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) …

Formulation Development, Characterization, and Evaluation of a Novel Dexibuprofen-Capsaicin Skin Emulgel with Improved In Vivo Anti-inflammatory and Analgesic …

IK Burki, MK Khan, BA Khan, B Uzair, VA Braga… - Aaps Pharmscitech, 2020 - Springer
Transdermal application of analgesics allows efficient and painless delivery of medication
with minimum side effect. This study was designed with the aim to formulate and …

Development of an intelligent, stimuli-responsive transdermal system for efficient delivery of Ibuprofen against rheumatoid arthritis

D Khan, M Qindeel, N Ahmed, MI Asad… - International Journal of …, 2021 - Elsevier
The present study aimed to fabricate and evaluate the therapeutic efficacy of pH-responsive
Ibuprofen (IB) nanoparticles (NPs) loaded transdermal hydrogel against rheumatoid arthritis …

Diadzein ameliorates 5-fluorouracil-induced intestinal mucositis by suppressing oxidative stress and inflammatory mediators in rodents

A Atiq, B Shal, M Naveed, A Khan, J Ali… - European journal of …, 2019 - Elsevier
Fluorouracil (5-FU) is one of the most commonly prescribed anti-cancer agent. However, its
use is associated with several debilitating adverse effects such as intestinal mucositis (IM) …

Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein …

H Ali, A Khan, J Ali, H Ullah, A Khan, H Ali… - BMC Pharmacology and …, 2020 - Springer
Background Acute lung injury (ALI) together with acute respiratory distress syndrome
(ARDS) are associated with high rate of mortality and morbidity in patients. In the current …