High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Background Osteoporosis has been one of the most common but largely under-diagnosed
clinical problems among elderly population. The disease burden is even greater in China …

Skeletal stem cells (SSCs) that are the major source of osteoblasts and adipocytes in adult
bone marrow express leptin receptor (LepR). To test whether LepR regulates SSC function …

Objective Data: Fat mass has been shown to increase in aging women; however, the extent
to which menopausal status mediates these changes remains unclear. The purpose of this …

Menopause nomenclature varies in the scholarly literature making synthesis and
interpretation of research findings difficult. Therefore, the present study aimed to review and …

Obesity is traditionally viewed to be beneficial to bone health because of well-established
positive effect of mechanical loading conferred by body weight on bone formation, despite …

Context: Body weight is the most important anthropometric determinant of bone mineral
density (BMD). Body weight is mainly made up of lean mass (LM) and fat mass (FM), and …

Beyond being aging-related diseases, atherosclerosis and osteoporosis share common
pathogenetic pathways implicated in bone and vascular mineralization. However, the …

With the progressive aging of the population, osteoporosis has gradually grown into a global
health problem for men and women aged 50 years and older because of its consequences …

Context: The relationship between obesity and osteoporosis has been widely studied, and
epidemiological evidence shows that obesity is correlated with increased bone mass …