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[HTML][HTML] A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer
Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
[HTML][HTML] HIF-1-independent mechanisms regulating metabolic adaptation in hypoxic cancer cells
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …
Exploration of 1, 2, 3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase
Abstract A novel series of 1, 2, 3-triazole benzenesulfonamide substituted 1, 3-
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
A strategy of Fenton reaction cycloacceleration for high‐performance ferroptosis therapy initiated by tumor microenvironment remodeling
L Huang, J Feng, J Zhu, J Yang… - Advanced …, 2023 - Wiley Online Library
The emerging tumor ferroptosis therapy confronts impediments of the tumor
microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H2O2, and a …
microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H2O2, and a …
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …
biochemical and physiological changes, which frequently influence the outcome of …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Ratiometric fluorescent probes for pH map** in cellular organelles
The intracellular pH (pHi) in organelles, including mitochondria, endoplasmic reticulum,
lysosomes, and nuclei, differs from the cytoplasmic pH, and thus maintaining the pH of these …
lysosomes, and nuclei, differs from the cytoplasmic pH, and thus maintaining the pH of these …
Drug delivery systems for localized cancer combination therapy
With over 2 million cancer cases and over 600,000 cancer-associated deaths predicted in
the US for 2022, this life-debilitating disease continuously impacts the lives of people across …
the US for 2022, this life-debilitating disease continuously impacts the lives of people across …
Recent progress in magnetically actuated microrobots for targeted delivery of therapeutic agents
Therapeutic agents, such as drugs and cells, play an essential role in virtually every
treatment of injury, illness, or disease. However, the conventional practices of drug delivery …
treatment of injury, illness, or disease. However, the conventional practices of drug delivery …
Metabolic tricks of cancer cells
K Hönigova, J Navratil, B Peltanova… - … et Biophysica Acta (BBA …, 2022 - Elsevier
One of the characteristics of cancer cells important for tumorigenesis is their metabolic
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …