[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease
J Nowell, E Blunt, D Gupta, P Edison - Ageing research reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …
[HTML][HTML] Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes
Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD)
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …
[HTML][HTML] Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer
JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …
hyperinsulinemia. However, recent data suggest a reverse order and place …
[HTML][HTML] Type 2 diabetes mellitus and Alzheimer's disease: shared molecular mechanisms and potential common therapeutic targets
R Hamzé, E Delangre, S Tolu, M Moreau… - International journal of …, 2022 - mdpi.com
The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …
with the aging of the population. Numerous epidemiological data suggest that there is a …
Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer's disease mouse models
The gut microbiota and microglia play critical roles in Alzheimer's disease (AD), and
elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in …
elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in …
[HTML][HTML] Glycogen synthase kinase-3 signaling in Alzheimer's disease
E Lauretti, O Dincer, D Praticò - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …
Type 3 diabetes and its role implications in Alzheimer's disease
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of develo** …
debate. However, poorly controlled blood sugar may increase the risk of develo** …
Inflammation: the link between comorbidities, genetics, and Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …
causative event. This has made the disease difficult to characterize and, thus, diagnose …
The cell biology of systemic insulin function
In this Beyond the Cell review, we focus on five stages of the journey of insulin through the
body and the captivating cell biology that underlies its connections with each organ. We …
body and the captivating cell biology that underlies its connections with each organ. We …
Alzheimer's disease prevention: from risk factors to early intervention
M Crous-Bou, C Minguillón, N Gramunt… - Alzheimer's research & …, 2017 - Springer
Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a
healthcare burden of epidemic proportions for which there is currently no cure …
healthcare burden of epidemic proportions for which there is currently no cure …