Molecular mechanisms underlying the effects of statins in the central nervous system

AJ McFarland, S Anoopkumar-Dukie, DS Arora… - International journal of …, 2014 - mdpi.com
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …

Statins in depression: an evidence-based overview of mechanisms and clinical studies

R De Giorgi, N Rizzo Pesci, A Quinton… - Frontiers in …, 2021 - frontiersin.org
Background: Depression is a leading cause of disability, burdened by high levels of non-
response to conventional antidepressants. Novel therapeutic strategies targeting non …

[HTML][HTML] Zebrafish: a new promise to study the impact of metabolic disorders on the brain

B Ghaddar, N Diotel - International journal of molecular sciences, 2022 - mdpi.com
Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …

In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major …

M Haghighi, S Khodakarami, L Jahangard… - Journal of psychiatric …, 2014 - Elsevier
Background The administration of statins seems to be a promising new avenue in the
treatment of patients suffering from major depressive disorder (MDD), though patients …

Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled …

SH Abbasi, P Mohammadinejad… - Journal of Affective …, 2015 - Elsevier
Background A decreased risk of develo** depression has been reported among statin
users. Aside from their lipid-lowering effects, statins are considered immunomodulatory …

Statin use and depression risk: a systematic review and meta-analysis

MC Lee, TR Peng, CH Lee, JY Wang, JA Lee… - Journal of Affective …, 2021 - Elsevier
Background Evidence regarding whether statin use is associated with depression is
inconsistent. Therefore, we performed a meta-analysis to investigate this association …

Statin for mood and inflammation among adult patients with major depressive disorder: an updated meta-analysis

X **ao, H Deng, P Li, J Sun, J Tian - Frontiers in Psychiatry, 2023 - frontiersin.org
Introduction Several small sample-sized clinical trials have demonstrated a beneficial effect
of statin on depressive mood among major depressive disorder (MDD) patients. However …

Drug repurposing may generate novel approaches to treating depression

ME Ebada - Journal of Pharmacy and Pharmacology, 2017 - academic.oup.com
Objectives The breakthrough advancements in scientific medical research have greatly
improved our understanding of the pathogenesis of depression, encouraging drug …

Pathophysiological mechanisms of post-myocardial infarction depression: a narrative review

E Garrels, T Kainth, B Silva, G Yadav, G Gill… - Frontiers in …, 2023 - frontiersin.org
Myocardial infarction (MI) can have significant physical and mental consequences.
Depression is a prevalent psychiatric condition after MI which can reduce the quality of life …

Rosuvastatin reduces neuroinflammation in the hemorrhagic transformation after rt-PA treatment in a mouse model of experimental stroke

D Lu, Y Liu, H Mai, J Zang, L Shen… - Frontiers in cellular …, 2018 - frontiersin.org
Hemorrhagic transformation (HT) is a serious complication that stimulates inflammation
during reperfusion therapy after acute ischemic stroke. Rosuvastatin, a 3-hydroxymethyl-3 …