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Molecular mechanisms underlying the effects of statins in the central nervous system
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …
Statins in depression: an evidence-based overview of mechanisms and clinical studies
Background: Depression is a leading cause of disability, burdened by high levels of non-
response to conventional antidepressants. Novel therapeutic strategies targeting non …
response to conventional antidepressants. Novel therapeutic strategies targeting non …
[HTML][HTML] Zebrafish: a new promise to study the impact of metabolic disorders on the brain
B Ghaddar, N Diotel - International journal of molecular sciences, 2022 - mdpi.com
Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …
In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major …
Background The administration of statins seems to be a promising new avenue in the
treatment of patients suffering from major depressive disorder (MDD), though patients …
treatment of patients suffering from major depressive disorder (MDD), though patients …
Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled …
SH Abbasi, P Mohammadinejad… - Journal of Affective …, 2015 - Elsevier
Background A decreased risk of develo** depression has been reported among statin
users. Aside from their lipid-lowering effects, statins are considered immunomodulatory …
users. Aside from their lipid-lowering effects, statins are considered immunomodulatory …
Statin use and depression risk: a systematic review and meta-analysis
MC Lee, TR Peng, CH Lee, JY Wang, JA Lee… - Journal of Affective …, 2021 - Elsevier
Background Evidence regarding whether statin use is associated with depression is
inconsistent. Therefore, we performed a meta-analysis to investigate this association …
inconsistent. Therefore, we performed a meta-analysis to investigate this association …
Statin for mood and inflammation among adult patients with major depressive disorder: an updated meta-analysis
Introduction Several small sample-sized clinical trials have demonstrated a beneficial effect
of statin on depressive mood among major depressive disorder (MDD) patients. However …
of statin on depressive mood among major depressive disorder (MDD) patients. However …
Drug repurposing may generate novel approaches to treating depression
ME Ebada - Journal of Pharmacy and Pharmacology, 2017 - academic.oup.com
Objectives The breakthrough advancements in scientific medical research have greatly
improved our understanding of the pathogenesis of depression, encouraging drug …
improved our understanding of the pathogenesis of depression, encouraging drug …
Pathophysiological mechanisms of post-myocardial infarction depression: a narrative review
Myocardial infarction (MI) can have significant physical and mental consequences.
Depression is a prevalent psychiatric condition after MI which can reduce the quality of life …
Depression is a prevalent psychiatric condition after MI which can reduce the quality of life …
Rosuvastatin reduces neuroinflammation in the hemorrhagic transformation after rt-PA treatment in a mouse model of experimental stroke
Hemorrhagic transformation (HT) is a serious complication that stimulates inflammation
during reperfusion therapy after acute ischemic stroke. Rosuvastatin, a 3-hydroxymethyl-3 …
during reperfusion therapy after acute ischemic stroke. Rosuvastatin, a 3-hydroxymethyl-3 …