Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a
cascade of reactions and induces activation of multiple internal defence mechanisms …

Gout is a picturesque presentation of uric acid disturbance. It is the most well understood
and described type of arthritis. Its epidemiology is studied. New insights into the …

Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …

Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

Sodium/glucose co‐transporter‐2 (SGLT2) inhibitors, which lower blood glucose by
increasing renal glucose elimination, have been shown to reduce the risk of adverse …

Hypertension is considered to be the most important risk factor in the development of
cardiovascular disease. An increasing body of evidence suggests that oxidative stress …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Uric acid, the end product of purine metabolism, is excreted predominantly by the proximal
tubules. Abnormal serum levels of uric acid are due to alterations in production or excretion …

Abstract Purpose of the Review Our review explores the epidemiology, physiology, and
clinical data surrounding the connection between hyperuricemia and metabolic syndrome …