Neurodevelopmental programming—the implementation of the genetic and epigenetic
blueprints that guide and coordinate normal brain development—requires tight regulation of …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in sha** later life disease risk-including susceptibility to …

Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

The focus of this overview is on the animal models of obesity most commonly utilized in
research. The models include monogenic models in the leptin pathway, polygenic diet …

There is a growing body of evidence from both human epidemiologic and animal studies
that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated …

Research has elucidated causal links between stress exposure and the development of
anxiety disorders, but due to the limited use of female or sex-comparative animal models …

The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …

The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism
and obesity in mammals. However, studies investigating the impact of the diet on the …

Background Maternal inflammation during pregnancy increases the risk for offspring
psychiatric disorders and other adverse long-term health outcomes. The influence of …