Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Nootropics, also known as “smart drugs” are a diverse group of medicinal substances whose
action improves human thinking, learning, and memory, especially in cases where these …

The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a
potentially powerful in vitro model for evaluating disease mechanisms and drug responses …

Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many
countries for treatment of cerebrovascular disorders such as stroke and dementia for more …

Background Vinpocetine is a synthetic ethyl ester of apovincamine, a vinca alkaloid
obtained from the leaves of the Lesser Periwinkle (Vinca minor) and discovered in the late …

Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been
used in the treatment of central nervous system disorders of cerebrovascular origin for …

Starting from the corresponding acetophenone and glycine derivatives, a series of new 3-
aminopyrroles was synthesized in few steps. Using this procedure with hydrazine and …

Alzheimer's disease (AD) is a neurodegenerative disease leading to cognitive and memory
impairment. This study aimed at investigating the therapeutic and preserving effects of …

Animal experiments, and particularly functional investigations on human chronically
epileptic tissue as well as genetic studies in epilepsy patients and their families strongly …

The Apocynaceae plant family contains a great number of so called eburnamine–vincamine
alkaloids. Quite a few of these alkaloids exert varied pharmacological activities on the cell …