T cell epitope predictions
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
Analysis of major histocompatibility complex (MHC) immunopeptidomes using mass spectrometry
The myriad of peptides presented at the cell surface by class I and class II major
histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and …
histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and …
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
The crystal structures of major histocompatibility complex (MHC) molecules contain a groove
occupied by heterogeneous material thought to represent peptides central to immune …
occupied by heterogeneous material thought to represent peptides central to immune …
Peptides naturally presented by MHC class I molecules.
MHC class I molecules are peptide receptors of stringent specificity which however still allow
millions of different ligands. This is achieved by the following specificity characteristics …
millions of different ligands. This is achieved by the following specificity characteristics …
Sequence analysis of peptides bound to MHC class II molecules
CD4 T cells recognize peptide fragments of foreign proteins bound to self class II molecules
of the major histocompatibility complex (MHC). Naturally processed peptide fragments …
of the major histocompatibility complex (MHC). Naturally processed peptide fragments …
Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
VIRUS-infected cells can be eliminated by cytotoxic T lymphocytes (CTL), which recognize
virus-derived peptides bound to major histocompatibility complex (MHC) class I molecules …
virus-derived peptides bound to major histocompatibility complex (MHC) class I molecules …
Exact prediction of a natural T cell epitope
T lymphocytes recognize their antigen as peptides associated with major histocompatibility
complex (MHC) molecules. Peptides naturally presented by MHC class I molecules are …
complex (MHC) molecules. Peptides naturally presented by MHC class I molecules are …
The sentinel within: exploiting the immune system for cancer biomarkers
The release of proteins from tumors triggers an immune response in cancer patients. These
tumor antigens arise from several mechanisms including tumor-specific alterations in protein …
tumor antigens arise from several mechanisms including tumor-specific alterations in protein …
Positive selection of thymocytes
Differentiation of αβ T cell receptor (TCR)-expressing T cells involves an obligatory
interaction with self-major histocompatibility complex (MHC) molecules in the thymus. This …
interaction with self-major histocompatibility complex (MHC) molecules in the thymus. This …
MHC class I immunopeptidome: past, present, and future
In the 35 years since the revelation that short peptides bound to major histocompatibility
complex class I and II molecules are the secret of the major histocompatibility complex …
complex class I and II molecules are the secret of the major histocompatibility complex …