Congenital disorders of glycosylation (CDG) are a rapidly expanding group of metabolic
disorders that result from abnormal protein or lipid glycosylation. They are often difficult to …

Complete knowledge of all direct and indirect interactions between proteins in a given cell
would represent an important milestone towards a comprehensive description of cellular …

Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain
strains of Escherichia coli. There is currently no available treatment for disease caused by …

Identification of effective combination therapies is critical to address the emergence of drug-
resistant cancers, but direct screening of all possible drug combinations is infeasible. Here …

Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of
one gene depends on the presence of a second, have enabled the systematic exploration of …

Immunotoxins are antibody-toxin bifunctional molecules that rely on intracellular toxin action
to kill target cells. Target specificity is determined via the binding attributes of the chosen …

Wnts are transported to the cell surface by the integral membrane protein WLS (also known
as Wntless, Evi, and GPR177). Previous studies of WLS trafficking have emphasized WLS …

Recycling of endocytic receptors to the cell surface involves passage through a series of
membrane-bound compartments by mechanisms that are poorly understood. In particular, it …

Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that
utilize glycans as their receptors have served as powerful tools to identify key players in …

Unconjugated monoclonal antibodies that target hematopoietic differentiation antigens have
been developed to treat hematologic malignancies. Although some of these have activity …