Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis

D Yuan, J Chu, H Lin, G Zhu, J Qian, Y Yu… - Frontiers in …, 2023 - frontiersin.org
Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …

Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

J Ouyang, L Sun, F Zeng, S Wu - Coordination Chemistry Reviews, 2022 - Elsevier
Fluorophores with aggregation-induced emission (AIE) are characterized by many
advantageous features for biomedical applications, including excellent photostability and …

[HTML][HTML] Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

CMC Andrés, JM Pérez de la Lastra, C Andrés Juan… - Cells, 2023 - mdpi.com
Hydrogen sulfide (H2S) was recognized as a gaseous signaling molecule, similar to nitric
oxide (-NO) and carbon monoxide (CO). The aim of this review is to provide an overview of …

Inflammatory mediators of endothelial dysfunction

E Dri, E Lampas, G Lazaros, E Lazarou, P Theofilis… - Life, 2023 - mdpi.com
Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and
vasoconstriction, elevated reactive oxygen species (ROS), and inflammatory factors, as well …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Sulfide regulation of cardiovascular function in health and disease

GK Kolluru, RE Shackelford, X Shen… - Nature Reviews …, 2023 - nature.com
Hydrogen sulfide (H2S) has emerged as a gaseous signalling molecule with crucial
implications for cardiovascular health. H2S is involved in many biological functions …

Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function

Y Ding, Y Zhou, P Ling, X Feng, S Luo, X Zheng… - …, 2021 - pmc.ncbi.nlm.nih.gov
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …

Lipid nanoparticles for nucleic acid delivery to endothelial cells

GW Liu, EB Guzman, N Menon, RS Langer - Pharmaceutical Research, 2023 - Springer
Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …