Under construction: The dynamic assembly, maintenance, and degradation of the cardiac sarcomere
The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein
complex with the actin and myosin filaments at its core. Assembling the sarcomere …
complex with the actin and myosin filaments at its core. Assembling the sarcomere …
Maintaining proteostasis under mechanical stress
Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …
functional protein networks even under conditions that threaten protein integrity. Protection …
Time-restricted feeding attenuates age-related cardiac decline in Drosophila
Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course
of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour …
of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour …
52 genetic loci influencing myocardial mass
Background: Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by …
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by …
Muscle‐derived exophers promote reproductive fitness
M Turek, K Banasiak, M Piechota, N Shanmugam… - EMBO …, 2021 - embopress.org
Muscle‐derived exophers promote reproductive fitness | EMBO reports Skip to Article Content
Skip to Article Information logo embp press logo JOURNALS The EMBO Journal The EMBO …
Skip to Article Information logo embp press logo JOURNALS The EMBO Journal The EMBO …
[HTML][HTML] The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans
L Gazda, W Pokrzywa, D Hellerschmied, T Löwe… - Cell, 2013 - cell.com
Summary The UCS (UNC-45/CRO1/She4) chaperones play an evolutionarily conserved
role in promoting myosin-dependent processes, including cytokinesis, endocytosis, RNA …
role in promoting myosin-dependent processes, including cytokinesis, endocytosis, RNA …
Pathogenic variants in the myosin chaperone UNC-45B cause progressive myopathy with eccentric cores
S Donkervoort, CE Kutzner, Y Hu, X Lornage… - The American Journal of …, 2020 - cell.com
The myosin-directed chaperone UNC-45B is essential for sarcomeric organization and
muscle function from Caenorhabditis elegans to humans. The pathological impact of UNC …
muscle function from Caenorhabditis elegans to humans. The pathological impact of UNC …
Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart
Amyloid-like inclusions have been associated with Huntington's disease (HD), which is
caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a …
caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a …
Prolonged exposure to microgravity reduces cardiac contractility and initiates remodeling in Drosophila
Understanding the effects of microgravity on human organs is crucial to exploration of low-
earth orbit, the moon, and beyond. Drosophila can be sent to space in large numbers to …
earth orbit, the moon, and beyond. Drosophila can be sent to space in large numbers to …
Ceramide-protein interactions modulate ceramide-associated lipotoxic cardiomyopathy
SM Walls, A Cammarato, DA Chatfield, K Ocorr… - Cell reports, 2018 - cell.com
Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of
lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is …
lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is …