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Trained immunity—basic concepts and contributions to immunopathology
Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …
Trained immunity: adaptation within innate immune mechanisms
J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity
G Liu, N Ma, K Cheng, Q Feng, X Ma, Y Yue… - Nature …, 2024 - nature.com
Trained immunity enhances the responsiveness of immune cells to subsequent infections or
vaccinations. Here we demonstrate that pre-vaccination with bacteria-derived outer …
vaccinations. Here we demonstrate that pre-vaccination with bacteria-derived outer …
Pathophysiology of COVID-19: why children fare better than adults?
The world is facing Coronavirus Disease-2019 (COVID-19) pandemic, which is causing a
large number of deaths and burden on intensive care facilities. It is caused by Severe Acute …
large number of deaths and burden on intensive care facilities. It is caused by Severe Acute …
BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
A series of epidemiological explorations has suggested a negative association between
national bacillus Calmette–Guérin (BCG) vaccination policy and the prevalence and …
national bacillus Calmette–Guérin (BCG) vaccination policy and the prevalence and …
[HTML][HTML] Prevention of tuberculosis in macaques after intravenous BCG immunization
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide.
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …
[HTML][HTML] BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment
B Cirovic, LCJ de Bree, L Groh, BA Blok, J Chan… - Cell host & …, 2020 - cell.com
Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates
beneficial heterologous effects, but the mechanisms underlying its persistence and …
beneficial heterologous effects, but the mechanisms underlying its persistence and …
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Abstract Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study
A Miller, MJ Reandelar, K Fasciglione, V Roumenova… - MedRxiv, 2020 - medrxiv.org
COVID-19 has spread to most countries in the world. Puzzlingly, the impact of the disease is
different in different countries. These differences are attributed to differences in cultural …
different in different countries. These differences are attributed to differences in cultural …
100 years of Mycobacterium bovis bacille Calmette-Guérin
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …