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Macrophage phagocytosis after spinal cord injury: when friends become foes
After spinal cord injury, macrophages can exert either beneficial or detrimental effects
depending on their phenotype. Aside from their critical role in inflammatory responses …
depending on their phenotype. Aside from their critical role in inflammatory responses …
Cell-based drug delivery systems with innate homing capability as a novel nanocarrier platform
Nanoparticle-based drug delivery systems have been designed to treat various diseases.
However, many problems remain, such as inadequate tumor targeting and poor therapeutic …
However, many problems remain, such as inadequate tumor targeting and poor therapeutic …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles
Neural stem cell (NSC) transplantation induces recovery in animal models of central
nervous system (CNS) diseases. Although the replacement of lost endogenous cells was …
nervous system (CNS) diseases. Although the replacement of lost endogenous cells was …
A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response
Microglia are increasingly implicated in brain pathology, particularly neurodegenerative
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
Chimeric antigen receptor macrophages activated through TLR4 or IFN-γ receptors suppress breast cancer growth by targeting VEGFR2
Chimeric antigen receptor macrophage (CAR-M) is a promising immunotherapy strategy of
anti-tumor due to its high infiltration, direct phagocytosis of tumor cells, immunomodulation of …
anti-tumor due to its high infiltration, direct phagocytosis of tumor cells, immunomodulation of …
The physiology of foamy phagocytes in multiple sclerosis
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …
Activation of the immune-metabolic receptor GPR84 enhances inflammation and phagocytosis in macrophages
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression
has been described predominantly in immune cells. GPR84 activation is involved in the …
has been described predominantly in immune cells. GPR84 activation is involved in the …
[HTML][HTML] APOE4 confers transcriptomic and functional alterations to primary mouse microglia
Common genetic variants in more than forty loci modulate risk for Alzheimer's disease (AD).
AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that …
AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that …
SFRP1 modulates astrocyte‐to‐microglia crosstalk in acute and chronic neuroinflammation
J Rueda‐Carrasco, MJ Martin‐Bermejo, G Pereyra… - EMBO …, 2021 - embopress.org
Neuroinflammation is a common feature of many neurodegenerative diseases. It fosters a
dysfunctional neuron–microglia–astrocyte crosstalk that, in turn, maintains microglial cells in …
dysfunctional neuron–microglia–astrocyte crosstalk that, in turn, maintains microglial cells in …