Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment
is a key event in cancer development and progression. In the last decade, emerging …

Liver disease is the spectrum of liver damage ranging from simple steatosis called as
nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). Clinically …

The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

Primary tumors and distant site metastases form a bidirectionally communicating system.
Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified …

The tumor microenvironment is a complex space comprised of normal, cancer and immune
cells. The macrophages are considered as the most abundant immune cells in tumor …

The majority of patients with diabetic macular edema (DME), the most common cause of
vision loss in working-age Americans, do not respond adequately to current therapies …

Hepatocellular carcinoma (HCC) is a solid tumor prone to chemotherapy resistance, and
combined immunotherapy is expected to bring a breakthrough in HCC treatment. However …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it
has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at …

The aim of the present study was to analyze the expression levels of angiopoietin-like 4
(ANGPTL4) in breast cancer to investigate the association between ANGPTL4 and breast …

Obesity is an established risk factor for several human cancers. Given the association
between excess body weight and cancer, the increasing rates of obesity worldwide are …