Ethical frameworks are the foundation for any research with humans or nonhuman animals.
Human research is guided by overarching international ethical principles, such as those …

Historical data from control groups in animal toxicity studies are currently mainly used for
comparative purposes to assess validity and robustness of study results. Due to the highly …

Translational neuroscience is committed to generating discoveries in the laboratory that
ultimately can improve human lives. Optogenetics has received considerable attention …

Decades of research studying the behavioral effects of damage to structures in medial
temporal lobe of rhesus monkeys have documented that such damage, particularly damage …

Chimeric antigen receptor (CAR) T cells have limited efficacy against solid tumors due to the
hostile microenvironment. Circulating tumor cells (CTCs) are essential to metastasis, which …

Objective To provide a comprehensive summary of the available evidence on the oral
microbiota of humans and non-human primates about the etiology of periodontal disease …

The social setting of animal subjects in the research environment has known effects on a
variety of dependent measures used in biomedical research. Proper evaluation of the …

Introduction Rhesus macaques are natural hosts to multiple viruses including rhesus
cytomegalovirus (RhCMV), rhesus rhadinovirus (RRV), and Simian Foamy Virus (SFV) …

Background Systemic inflammatory response remains a poorly understood cause of
morbidity and mortality after traumatic injury. Recent nonhuman primate (NHP) trauma …

Acoustic noise and other environmental variables represent potential confounds for animal
research. Of relevance to auditory research, sustained high levels of ambient noise may …