In recent years, with the advent of next-generation sequencing along with the development
of various bioinformatics tools, RNA sequencing (RNA-Seq)-based transcriptome analysis …

The zebrafish holds much promise as a high-throughput drug screening model for immune-
related diseases, including inflammatory and infectious diseases and cancer. This is due to …

Studying macrophage biology in the context of a whole living organism provides unique
possibilities to understand the contribution of this extremely dynamic cell subset in the …

Autophagy is an important defense mechanism against mycobacteria, the causative agents
of tuberculosis. The molecular mechanisms that link mycobacterial recognition to autophagy …

The zebrafish has proven itself as an excellent model to study vertebrate innate immunity. It
presents us with possibilities for in vivo imaging of host‐pathogen interactions which are …

Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on
the autophagy machinery of the host. This response is studied intensively in epithelial cells …

Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC)
development. Here, we studied the involvement of RIG-I-like receptors (RLRs) in HSPC …

Background MicroRNAs (miRNAs) have recently been shown to play important roles in
development of the immune system and in fine-tuning of immune responses. Human miR …

Zebrafish model systems for infectious disease are increasingly used for the functional
analysis of molecular pattern recognition processes. These studies benefit from the high …

Glucocorticoids are steroid hormones that are secreted upon stress. Their effects are
mediated by the glucocorticoid receptor, which acts as a transcription factor. Because the …