Abstract Neural Tube Defects are the most typical congenital malformations, with almost
300,000 cases annually worldwide. The incidence varies amongst geographical ranges …

The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis,
originate from a failure of the embryonic neural tube to close. Human NTD are relatively …

Post-zygotic mutations that generate tissue mosaicism are increasingly associated with
severe congenital defects, including those arising from failed neural tube closure. Here we …

Lack or excess expression of the surface ectoderm-expressed transcription factor
Grainyhead-like2 (Grhl2), each prevent spinal neural tube closure. Here we investigate the …

Neural tube defects (NTDs) are among the most common birth defects, with a prevalence of
close to 19 per 10,000 births worldwide. The etiology of NTDs is complex involving the …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

Neurulation is a critical step in early embryonic development, giving rise to the neural tube,
the primordium of the central nervous system in amniotes. Understanding this complex, multi …

Among the transcription factors that are conserved across phylogeny, the grainyhead family
holds vital roles in driving the epithelial cell fate. In Drosophila, the function of grainyhead …

Grainyhead-like 2 (GRHL2), one of the three homologs of Drosophila grainyhead,
contributes to epithelial morphogenesis and differentiation. Dysregulation of GRHL2 has …

Neural tube defects (NTDs), including spina bifida and anencephaly, are among the most
common birth defects worldwide, but their underlying genetic and cellular causes are not …