The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

Ketamine (Ket) was developed in 1962 as a less hallucinogenic and shorter acting agent
than phencyclidine. It was given to humans for the first time in 1964. However, Ket produces …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Abstract Bacopa monnieri (Linn.) Wettst. has been used in traditional medicine as a drug to
enhance and improve memory. In this regard, this study aims to provide B. monnieri's …

Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …

Introduction: Despite the availability of new vaccines for SARS-CoV-2, there has been slow
uptake and problems with supply in some parts of the world. Hence, there is still a necessity …

The sigma-1 receptor (S1R) is a 223 amino acid-long transmembrane endoplasmic
reticulum (ER) protein. The S1R modulates the activity of multiple effector proteins, but its …

Depression is a condition characterized by low mood and an aversion to activity, that causes
behavioral problems, poor quality of life and limits daily life activities. It is considered as the …

Though a great many of studies on the development of antidepressants for the therapy of
major depression disorder (MDD) and the development of antidepressants have been …

Introduction The sigma receptors are found abundantly in the central nervous system and
are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's …