Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …

Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

Background: Cells respond to environmental stressors through several key pathways,
including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA …

Mammalian mitochondria contain multiple small genomes. While these organelles have
efficient base excision removal of oxidative DNA lesions and alkylation damage, many DNA …

Because of the role that DNA damage and depletion play in human disease, it is important to
develop and improve tools to assess these endpoints. This unit describes PCR‐based …

Mitochondrial dysfunction has been linked to myriad human diseases and toxicant
exposures, highlighting the need for assays capable of rapidly assessing mitochondrial …

Neurodegeneration has been correlated with mitochondrial DNA (mtDNA) damage and
exposure to environmental toxins, but causation is unclear. We investigated the ability of …

Caenorhabditis elegans is an important model used for many aspects of biological research.
Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the …

Mitochondria are critical for their role in ATP production as well as multiple nonenergetic
functions, and mitochondrial dysfunction is causal in myriad human diseases. Less well …