Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and
radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and …

Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …

Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Foods high in carbohydrates are an important part of a healthy diet, since they provide the
body with glucose to support bodily functions and physical activity. However, the abusive …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing
damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi …