Experimental treatment strategies and neuroprotective drugs that showed therapeutic
promise in animal models of stroke have failed to produce beneficial effects in human stroke …

Rodents are the most widely used experimental animals in stroke research due to their
similar vascular anatomy, high reproductive rates, and availability of transgenic models …

Background and Purpose—The selection of appropriate neurological scores and tests is
crucial for the evaluation of stroke consequences. The validity and reliability of neurological …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Resting heart rate is central to cardiac output and is influenced by changes occurring in
numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence …

After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …

Some 40 years ago it was recognized by Furchgott and colleagues that the endothelium
releases a vasodilator, endothelium-derived relaxing factor (EDRF). Later on, several …

Statins have been widely used for the treatment of a variety of conditions beyond their
original role in lowering cholesterol. Since statins have relatively few side effects, they have …

Ischemic stroke accounts for nearly 80% of stroke cases. Recanalization with thrombolysis is
a currently crucial therapeutic strategy for re-building blood supply, but the thrombolytic …

Abstract Significance and Recent Advances: Ischemic stroke is the leading cause of
disability and third in mortality in industrialized nations. Immediate restoration of cerebral …