Bioorthogonal chemistry for prodrug activation in vivo

Q Fu, S Shen, P Sun, Z Gu, Y Bai, X Wang… - Chemical Society …, 2023 - pubs.rsc.org
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Metal complexes for catalytic and photocatalytic reactions in living cells and organisms

H Madec, F Figueiredo, K Cariou, S Roland… - Chemical …, 2023 - pubs.rsc.org
The development of organometallic catalysis has greatly expanded the synthetic chemist
toolbox compared to only exploiting “classical” organic chemistry. Although more widely …

Transition metal catalysis in living cells: progress, challenges, and novel supramolecular solutions

CC James, B de Bruin, JNH Reek - Angewandte Chemie, 2023 - Wiley Online Library
The importance of transition metal catalysis is exemplified by its wide range of applications,
for example in the synthesis of chemicals, natural products, and pharmaceuticals. However …

Bioorthogonal nanozymes: an emerging strategy for disease therapy

Z Zhang, K Fan - Nanoscale, 2023 - pubs.rsc.org
Transition metal catalysts (TMCs), capable of performing bioorthogonal reactions, have
been engineered to trigger the formation of bioactive molecules in a controlled manner for …

De Novo Engineering of Pd-Metalloproteins and Their Use as Intracellular Catalysts

S Learte-Aymamí, L Martínez-Castro… - JACS Au, 2024 - ACS Publications
The development of transition metal-based catalytic platforms that promote bioorthogonal
reactions inside living cells remains a major challenge in chemical biology. This is …