Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Advances in population-scale genomic sequencing have greatly expanded the
understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of these …

The 2013 discovery of calreticulin (CALR) mutations in myeloproliferative neoplasms was
attended by their association with longer survival in primary myelofibrosis (PMF) …

The most important prognostic factor for atherosclerotic cardiovascular disease is age,
independent of all other recognized risk factors. Recently, exome sequence analyses …

Clonal hematopoiesis is a common, age-related process in which a somatically mutated
hematopoietic precursor gives rise to a genetically distinct subpopulation in the blood. This …

Myeloproliferative neoplasms (MPNs) have estimated annual incidence rates for
polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis of 0.84 …

Genetic predisposition due to germline mutations in a number of genes (eg, ETV6, GATA2,
and RUNX1) has been recognized as an important cause of myeloid malignancies. In the …

Simple Summary There is growing evidence that Ph-negative myeloproliferative neoplasms
are disorders in which multiple signaling pathways are significantly disturbed. The …

Myeloproliferative neoplasms (MPNs) are haematopoietic stem cell-derived clonal disorders
characterised by proliferation of some or all myeloid lineages, depending on the subtype …