Liver disease is a significant health problem worldwide with mortality reaching around 2
million deaths a year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease …

Liver fibrosis is the representative features of liver chronic inflammation and the
characteristic of early cirrhosis. To date, effective therapy for liver fibrosis is lacking …

Pentoxifylline (PTX) is a non-selective phosphodiesterase inhibitor with the effects of
antioxidation, anti-inflammation and anti-fibrosis that has been shown to induce damage in …

Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis.
Phosphatase and tension homolog deleted on chromosome 10 (PTEN) is a negative …

The aim of this study was to investigate the effects of tadalafil (TDF) and pentoxifylline (PTX)
on hepatic apoptosis and the expressions of endothelial and inducible nitric oxide synthases …

Objective (s): Carbon tetrachloride (CCL 4) toxicity triggers fibrosis, activating various
mechanisms within the cell. We aimed to create damage with CCL 4 and investigate the …

We investigated the combinatorial effects of pentoxifylline (PTX) on the efficacy of
gemcitabine (GEM) in a human pancreatic tumor xenograft model. PTX significantly …

Background: 3-4methylenedioxymethamphetamine (MDMA) is a synthetic and psychoactive
drug, which is known popularly as Ecstasy and has toxic effects on human organs …

The scarcity of donors has prompted the growing utilization of steatotic livers, which are
susceptible to injuries following orthotopic liver transplantation (OLT). This study aims to …

Background: It is well known that the hippocampus, the CA1 Pyramidal cells in particular, is
selectively vulnerable during global cerebral ischemia. Recently, it is observed that …