Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection
and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences …

Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …

The extensive array of morphological diversity among animal taxa represents the product of
millions of years of evolution. Morphology is the output of development, therefore phenotypic …

Adult skeletal muscle is a highly plastic tissue that readily reduces or gains its mass in
response to mechanical and metabolic stimulation; however, the upstream mechanisms that …

The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …

Geometry is a fundamental attribute of biological systems, and it underlies cell and tissue
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …