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Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
The emergence of artemisinin partial resistance in Africa: how do we respond?
Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …
Evolution of partial resistance to artemisinins in malaria parasites in Uganda
MD Conrad, V Asua, S Garg… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …
component of artemisinin-based combination therapies, the most important malaria drugs …
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
Antimalarial drug resistance: a threat to malaria elimination
Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
Antimalarial drug resistance in Africa: the calm before the storm?
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
D Ménard, N Khim, J Beghain… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that …
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that …
Artemisinin action and resistance in Plasmodium falciparum
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
Artemisinin-Resistant Plasmodium falciparum Malaria
RM Fairhurst, AM Dondorp - Microbiology spectrum, 2016 - journals.asm.org
For more than five decades, Southeast Asia (SEA) has been fertile ground for the
emergence of drug-resistant Plasmodium falciparum malaria. After generating parasites …
emergence of drug-resistant Plasmodium falciparum malaria. After generating parasites …
Are malaria elimination efforts on right track? An analysis of gains achieved and challenges ahead
S Dhiman - Infectious diseases of poverty, 2019 - Springer
Background Malaria causes significant morbidity and mortality each year. In the past few
years, the global malaria cases have been declining and many endemic countries are …
years, the global malaria cases have been declining and many endemic countries are …