Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa

PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

The emergence of artemisinin partial resistance in Africa: how do we respond?

PJ Rosenthal, V Asua, JA Bailey… - The Lancet Infectious …, 2024 - thelancet.com
Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …

Evolution of partial resistance to artemisinins in malaria parasites in Uganda

MD Conrad, V Asua, S Garg… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …

Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

PK Tumwebaze, MD Conrad, M Okitwi, S Orena… - Nature …, 2022 - nature.com
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

Antimalarial drug resistance: a threat to malaria elimination

D Menard, A Dondorp - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

Antimalarial drug resistance in Africa: the calm before the storm?

MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

D Ménard, N Khim, J Beghain… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that …

Artemisinin action and resistance in Plasmodium falciparum

L Tilley, J Straimer, NF Gnädig, SA Ralph… - Trends in …, 2016 - cell.com
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Artemisinin-Resistant Plasmodium falciparum Malaria

RM Fairhurst, AM Dondorp - Microbiology spectrum, 2016 - journals.asm.org
For more than five decades, Southeast Asia (SEA) has been fertile ground for the
emergence of drug-resistant Plasmodium falciparum malaria. After generating parasites …

Are malaria elimination efforts on right track? An analysis of gains achieved and challenges ahead

S Dhiman - Infectious diseases of poverty, 2019 - Springer
Background Malaria causes significant morbidity and mortality each year. In the past few
years, the global malaria cases have been declining and many endemic countries are …