Breakthrough treatments for accelerated wound healing
Skin injuries across the body continue to disrupt everyday life for millions of patients and
result in prolonged hospital stays, infection, and death. Advances in wound healing devices …
result in prolonged hospital stays, infection, and death. Advances in wound healing devices …
Advanced bandages for diabetic wound healing
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes,
remain nonspecific. In this Perspective, we present recent advances in understanding the …
remain nonspecific. In this Perspective, we present recent advances in understanding the …
A strain-programmed patch for the healing of diabetic wounds
Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with
bioengineered skin or with growth factors. However, most patients do not benefit from these …
bioengineered skin or with growth factors. However, most patients do not benefit from these …
Recent advances in responsive hydrogels for diabetic wound healing
S Zhang, G Ge, Y Qin, W Li, J Dong, J Mei, R Ma… - Materials Today Bio, 2023 - Elsevier
Poor wound healing after diabetes mellitus remains a challenging problem, and its
pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding …
pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding …
Single cell transcriptomic landscape of diabetic foot ulcers
Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …
remains incompletely understood. Here, we profile 174,962 single cells from the foot …
Myofibroblasts: function, formation, and scope of molecular therapies for skin fibrosis
Y Tai, EL Woods, J Dally, D Kong, R Steadman… - Biomolecules, 2021 - mdpi.com
Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …
Inflammatory microenvironment of skin wounds
Z Wang, F Qi, H Luo, G Xu, D Wang - Frontiers in immunology, 2022 - frontiersin.org
Wound healing is a dynamic and highly regulated process that can be separated into three
overlap** and interdependent phases: inflammation, proliferation, and remodelling. This …
overlap** and interdependent phases: inflammation, proliferation, and remodelling. This …
Multistage ROS-responsive and natural polyphenol-driven prodrug hydrogels for diabetic wound healing
Z Ni, H Yu, L Wang, Y Huang, H Lu… - ACS applied materials …, 2022 - ACS Publications
The high level of reactive oxygen species (ROS) and bacterial infection impede wound
healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid …
healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid …
Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice
Diabetic foot ulceration is a devastating diabetic complication with unmet needs. We
explored the efficacy of calcium-crosslinked alginate dressings in topically delivering …
explored the efficacy of calcium-crosslinked alginate dressings in topically delivering …
Integrated skin transcriptomics and serum multiplex assays reveal novel mechanisms of wound healing in diabetic foot ulcers
Nonhealing diabetic foot ulcers (DFUs) are characterized by low-grade chronic
inflammation, both locally and systemically. We prospectively followed a group of patients …
inflammation, both locally and systemically. We prospectively followed a group of patients …