Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Tubulointerstitial inflammation is a common characteristic of acute and chronic kidney injury.
However, the mechanism by which the initial injury of tubular epithelial cells (TECs) drives …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although
AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Kidney fibrosis is the final common pathway of progressive kidney diseases, the underlying
mechanisms of which are not fully understood. The purpose of the current study is to …

Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all
progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide …

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM),
leading to destruction of normal kidney architecture and loss of renal function. The activation …

Cellular senescence is associated with renal disease progression, and accelerated tubular
cell senescence promotes the pathogenesis of renal fibrosis. However, the underlying …

Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …