Background Several theories propose alternative explanations for drug addiction. Objectives
We propose a general theory of transition to addiction that synthesizes knowledge …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

In this brief review, we describe current computational models of drug-use and addiction that
fall into 2 broad categories: mathematically based models that rely on computational …

Behavioral models are central to behavioral neuroscience. To study the neural mechanisms
of maladaptive behaviors (including binge eating and drug addiction), it is essential to …

Rationale The motivational impetuses underlying self-administration of cocaine and other
drugs of abuse are not fully understood. One emerging factor is affect. Both positive and …

Habits have garnered significant interest in studies of associative learning and maladaptive
behavior. However, habit research has faced scrutiny and challenges related to the …

Identifying effective pharmacological treatments for addictive disorders has remained an
elusive goal. Many different classes of drugs have shown some efficacy in preclinical …

Goal‐directed and habitual decision‐making are fundamental processes that support the
ongoing adaptive behavior. There is a growing interest in examining their disruption in …

Habits are theorized to play a key role in compulsive cocaine seeking, yet there is limited
methodology for assessing habitual responding for intravenous (IV) cocaine. We developed …

To more effectively manage substance use disorders, it is imperative to understand the
neural, genetic, and psychological underpinnings of addictive behavior. To contribute to this …