Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment

Z He, W Chen, K Hu, Y Luo, W Zeng, X He, T Li… - Nature …, 2024 - nature.com
The buildup of plaques in atherosclerosis leads to cardiovascular events, with chronic
unresolved inflammation and overproduction of reactive oxygen species (ROS) being major …

Trained immunity: adaptation within innate immune mechanisms

J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

[HTML][HTML] Protein-based nanoparticles as drug delivery systems

S Hong, DW Choi, HN Kim, CG Park, W Lee, HH Park - Pharmaceutics, 2020 - mdpi.com
Nanoparticles have been extensively used as carriers for the delivery of chemicals and
biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural …

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

C Gao, Q Huang, C Liu, CHT Kwong, L Yue… - Nature …, 2020 - nature.com
Vascular disease remains the leading cause of death and disability, the etiology of which
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …

HDL and reverse cholesterol transport: Basic mechanisms and their roles in vascular health and disease

M Ouimet, TJ Barrett, EA Fisher - Circulation research, 2019 - ahajournals.org
Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

Macrophages in atherosclerosis regression

TJ Barrett - Arteriosclerosis, thrombosis, and vascular biology, 2020 - ahajournals.org
Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

J Liu, Z Liu, Y Pang, H Zhou - Journal of Nanobiotechnology, 2022 - Springer
Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of
different materials and adjustment of their physical and chemical properties, nanoparticles …

Targeting the microenvironment of vulnerable atherosclerotic plaques: an emerging diagnosis and therapy strategy for atherosclerosis

S Zhang, Y Liu, Y Cao, S Zhang, J Sun… - Advanced …, 2022 - Wiley Online Library
Atherosclerosis is considered one of the primary causes of cardiovascular diseases (CVDs).
Unpredictable rupture of the vulnerable atherosclerotic plaques triggers adverse …