Mammalian development requires effective mechanisms to repress genes whose
expression would generate inappropriately specified cells. The Polycomb-repressive …

Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form
protofilaments that associate laterally in varying numbers. It is not known how cellular …

The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …

Recognition of modified histones by 'reader'proteins plays a critical role in the regulation of
chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the …

During infection, circulating blood monocytes migrate from the vasculature to the
extravascular compartments where they mature into tissue macrophages. The maturation …

CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …

DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …

The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …

Background & Aims: The intestine-specific transcription factors Cdx1 and Cdx2 are
candidate genes for directing intestinal development, differentiation, and maintenance of the …

The multisubunit Mediator, comprising∼ 30 distinct proteins, plays an essential role in gene
expression regulation by acting as a bridge between DNA-binding transcription factors and …