The interaction of regulatory proteins with the complex nucleoprotein structures that are
found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms …

Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale map** of replication …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

Eukaryotic genomes are compacted into loops and topologically associating domains
(TADs),–, which contribute to transcription, recombination and genomic stability,. Cohesin …

We describe a procedure for designing proteins with backbones produced by varying the
parameters in the Crick coiled coil–generating equations. Combinatorial design calculations …

Cell proliferation is a fundamental requirement for organismal development and
homeostasis. The mammalian cell division cycle is tightly controlled to ensure complete and …

Minichromosome maintenance proteins (MCMs) are DNA-dependent ATPases that bind to
replication origins and license them to support a single round of DNA replication. A large …

Because of cellular heterogeneity, the analysis of endogenous molecules from single cells is
of significant interest and has major implications. While micromanipulation or cell sorting …

Resolution of replication forks during termination of DNA replication is essential for accurate
duplication of eukaryotic genomes. Here we present evidence consistent with the idea that …

Excess dormant origins bound by the minichromosome maintenance (MCM) replicative
helicase complex play a critical role in preventing replication stress, chromosome instability …