Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria

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Cellular prion protein is present in mitochondria of healthy mice

R Faris, RA Moore, A Ward, B Race, DW Dorward… - Scientific reports, 2017 - nature.com
Cellular prion protein (PrPC) is a mammalian glycoprotein which is usually found anchored
to the plasma membrane via a glycophosphatidylinositol (GPI) anchor. PrPC misfolds to a …
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[HTML][HTML] 1-L Transcription in Prion Diseases

J Nahalka - International Journal of Molecular Sciences, 2024 - mdpi.com
Understanding the pathogenesis and mechanisms of prion diseases can significantly
expand our knowledge in the field of neurodegenerative diseases. Prion biology is …
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Aberrant alterations of mitochondrial factors Drp1 and Opa1 in the brains of scrapie experiment rodents

XD Yang, Q Shi, J Sun, Y Lv, Y Ma, C Chen… - Journal of Molecular …, 2017 - Springer
The abnormal mitochondrial dynamics has been reported in the brains of some
neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease …
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