Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …

In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue
Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion …

Objective The disordered growth of nerve stumps after amputation leading to the formation
of neuromas is an important cause of postoperative pain in amputees. This severely affects …

Background: Skeletal muscle injuries represent a major concern in sports medicine. Cell
therapy has emerged as a promising therapeutic strategy for muscle injuries, although the …

Wound healing requires a complex cascade of highly controlled and conserved cellular and
molecular processes. These involve numerous cell types and extracellular matrix molecules …

Aging is associated with both muscle weakness and a loss of muscle mass, contributing
towards overall frailty in the elderly. Aging skeletal muscle is also characterised by a …

Radiation exposure accelerates the onset of age-related diseases such as diabetes,
cardiovascular disease, and neoplasia and, thus, lends insight into in vivo mechanisms …

Muscle regeneration is impaired in the aged organism, due to both intrinsic defects of
muscle stem cells (MuSCs) and alterations of their environmental niche. However, the latter …

Background: Eccentric muscle contractions are commonly used in exercise regimens, as
well as in rehabilitation as a treatment against muscle atrophy and weakness. If repeated …

Fibrosis is a detrimental disease that causes organ failure with no effective therapy available
to date. Activated fibroblasts-myofibroblasts-are responsible for the excessive secretion of …