[HTML][HTML] mRNA-based therapeutics—develo** a new class of drugs
In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
Therapeutic cancer vaccines: past, present, and future
Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …
to treat late stage disease by using a patient's own immune system. The promising results …
Clinical and immunological effects of mRNA vaccines in malignant diseases
In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and
highly efficient class of drugs. Several recently published studies emphasize the potential …
highly efficient class of drugs. Several recently published studies emphasize the potential …
Dendritic cell–based immunotherapy: state of the art and beyond
KF Bol, G Schreibelt, WR Gerritsen, IJM De Vries… - Clinical cancer …, 2016 - AACR
Dendritic cell (DC) vaccination in cancer patients aims to induce or augment an effective
antitumor immune response against tumor antigens and was first explored in a clinical trial …
antitumor immune response against tumor antigens and was first explored in a clinical trial …
Phase II study of autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) plus ipilimumab in patients with pretreated advanced melanoma
S Wilgenhof, J Corthals, C Heirman… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Autologous monocyte-derived dendritic cells (DCs) electroporated with synthetic
mRNA (TriMixDC-MEL) are immunogenic and have antitumor activity as a monotherapy in …
mRNA (TriMixDC-MEL) are immunogenic and have antitumor activity as a monotherapy in …
Dendritic cell therapy in cancer treatment; the state-of-the-art
Dendritic cells (DCs) are considered as professional antigen presenting cells (APCs),
containing a variety of subsets, that can be resident in organs or migrating among the …
containing a variety of subsets, that can be resident in organs or migrating among the …
Engineered nucleic acids encoding a modified erythropoietin and their expression
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Dendritic cells as orchestrators of anticancer immunity and immunotherapy
I Heras-Murillo, I Adán-Barrientos, M Galán… - Nature Reviews …, 2024 - nature.com
Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …
that regulate adaptive immunity, including against cancer. Therefore, understanding the …
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is
exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor …
exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor …
mRNA therapeutics in cancer immunotherapy
JD Beck, D Reidenbach, N Salomon, U Sahin… - Molecular cancer, 2021 - Springer
Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment
or peptide and lends itself to a broad range of pharmaceutical applications, including …
or peptide and lends itself to a broad range of pharmaceutical applications, including …