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[HTML][HTML] RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
A Shannon, V Fattorini, B Sama, B Selisko… - Nature …, 2022 - nature.com
The guanosine analog AT-527 represents a promising candidate against Severe Acute
Respiratory Syndrome coronavirus type 2 (SARS-CoV-2). AT-527 recently entered phase III …
Respiratory Syndrome coronavirus type 2 (SARS-CoV-2). AT-527 recently entered phase III …
[HTML][HTML] Rotaviruses
U Desselberger - Virus research, 2014 - Elsevier
Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …
determination of the RV particle structure and functions of structural proteins, classification …
[HTML][HTML] Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy
The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …
Structure of the respiratory syncytial virus polymerase complex
Numerous interventions are in clinical development for respiratory syncytial virus (RSV)
infection, including small molecules that target viral transcription and replication. These …
infection, including small molecules that target viral transcription and replication. These …
Structures of influenza A proteins and insights into antiviral drug targets
K Das, JM Aramini, LC Ma, RM Krug… - Nature structural & …, 2010 - nature.com
The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-
called'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and …
called'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and …
Common and unique features of viral RNA-dependent polymerases
AJW Te Velthuis - Cellular and molecular life sciences, 2014 - Springer
Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …
these pathogens share little sequence similarity and use different replication and …
[HTML][HTML] Structure and functionality in flavivirus NS-proteins: perspectives for drug design
M Bollati, K Alvarez, R Assenberg, C Baronti, B Canard… - Antiviral research, 2010 - Elsevier
Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …