Highlights•Drug discovery has been advanced to a big data era with a large amount of
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …

Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

To the Editor—Reconstructing metabolic reaction networks enables the development of
testable hypotheses of an organism's metabolism under different conditions 1. State-of-the …

Computational modelling has become increasingly common in life science research. To
provide a platform to support universal sharing, easy accessibility and model reproducibility …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …

High-throughput technologies, offering an unprecedented wealth of quantitative data
underlying the makeup of living systems, are changing biology. Notably, the systematic …

Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as …

Introduction The human genome-scale metabolic reconstruction details all known metabolic
reactions occurring in humans, and thereby holds substantial promise for studying complex …

Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process
driven in part by telomere shortening, has been implicated in age‐related tissue dysfunction …