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Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Physical principles underlying the complex biology of intracellular phase transitions
Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …
have the hallmarks of intracellular phase transitions. This suggests that a common …
Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation
has important implications for analysing cellular function, treating disease and designing …
has important implications for analysing cellular function, treating disease and designing …
Evidence for widespread cytoplasmic structuring into mesoscale condensates
Compartmentalization is an essential feature of eukaryotic life and is achieved both via
membrane-bound organelles, such as mitochondria, and membrane-less biomolecular …
membrane-bound organelles, such as mitochondria, and membrane-less biomolecular …
Precise prediction of phase-separation key residues by machine learning
J Sun, J Qu, C Zhao, X Zhang, X Liu, J Wang… - Nature …, 2024 - nature.com
Understanding intracellular phase separation is crucial for deciphering transcriptional
control, cell fate transitions, and disease mechanisms. However, the key residues, which …
control, cell fate transitions, and disease mechanisms. However, the key residues, which …
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
Prediction of liquid–liquid phase separating proteins using machine learning
Background The liquid–liquid phase separation (LLPS) of biomolecules in cell underpins
the formation of membraneless organelles, which are the condensates of protein, nucleic …
the formation of membraneless organelles, which are the condensates of protein, nucleic …
Molecular and environmental determinants of biomolecular condensate formation
JA Villegas, M Heidenreich, ED Levy - Nature chemical biology, 2022 - nature.com
Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …
and has found relevance in biology and disease. Understanding the physical principles and …
Properties of stress granule and P-body proteomes
Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form
by the phase separation of RNAs and proteins. They participate in translational control and …
by the phase separation of RNAs and proteins. They participate in translational control and …