Background Gastric cancer imposes a substantial global health burden despite its overall
incidence decrease. A broad spectrum of inherited, environmental and infectious factors …

Sphingolipids containing acyl residues that are hydroxylated at C-2 are found in most, if not
all, eukaryotes and certain bacteria. 2-hydroxylated sphingolipids are present in many …

Patients with persistent ulcerative colitis (UC) are at a higher risk of develo** colitis-
associated cancer (CAC). Previous studies have reported that intestinal microbiota …

Whereas it is appreciated that cancer cells rewire lipid metabolism to survive and propagate,
the roles of lipid metabolism in metastasis remain largely unknown. In this study, using …

Background Different methods for digestive tract reconstruction have a complex impact on
the nutritional status of gastric cancer (GC) patients after radical gastrectomy. Previous …

Gastric cancer (GC) is a common malignant tumor in the digestive tract and a major cause of
global cancer death. Due to the limited access to early screening, many patients are …

Recurrent major depressive disorder (rMDD) is a relapsing-remitting disease with high
morbidity and a 5-year risk of recurrence of up to 80%. This was a prospective pilot study to …

Alteration in lipid composition is an important metabolic adaptation by cancer cells to
support tumorigenesis and metastasis. Fatty acid 2-hydroxylase (FA2H) introduces a chiral …

Intestinal inflammation is a vital precipitating factor of colorectal cancer (CRC), but the
underlying mechanisms are still elusive. TANK-binding kinase 1 (TBK1) is a core enzyme …

Glycerophospholipid signal and fatty acid metabolism are closely related to the occurrence
and progression of tumours, and metabolic reprogramming caused by hydrolytic enzymes …