Background Organ transplantation is predicted to increase as life expectancy and the
incidence of chronic diseases rises. Regenerative medicine-inspired technologies …

Recent demonstrations of human brain organoid transplantation in rodents have
accentuated ethical concerns associated with these entities, especially as they relate to …

A central question for regenerative neuroscience is whether synthetic neural circuits, such
as those built from two species, can function in an intact brain. Here, we apply blastocyst …

Growing human organs in animals sounds like something from the realm of science fiction,
but it may one day become a reality through a technique known as interspecies blastocyst …

Interspecies blastocyst complementation (IBC) provides a unique platform to study
development and holds the potential to overcome worldwide organ shortages. Despite …

Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential
for functional genomics and biomedical research, which require germline transmission for …

The three-dimensional genome structure organized by CTCF is required for development.
Clinically identified mutations in CTCF have been linked to adverse developmental …

Rationale: The regeneration and replacement of lung cells or tissues from induced
pluripotent stem cell–or embryonic stem cell–derived cells represent future therapies for life …

Generating organs from stem cells through blastocyst complementation is a promising
approach to meet the clinical need for transplants. In order to generate rejection-free organs …

Blastocyst complementation denotes a technique that aims to generate organs, tissues, or
cell types in animal chimeras via injection of pluripotent stem cells (PSCs) into genetically …